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Product Name
Histone H3 Rabbit pAb (HRP)
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Gene ID
8350
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SwissProt ID
P68431
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Gene Name
H3C1
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Alternative Names
H3 histone; HIST1H3A; Histone cluster 1; H3a
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Background
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.MiscellaneousThis histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of Lys-10 (H3K9me2).
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Loading Control antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB
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Dilution Ratio
WB: 1/5000-1/10000
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Molecular Weight
Calculated MW: 15 kDa; Observed MW: 15 kDa
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Clonality
Polyclonal Antibody
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Clonality No.
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Isotype
IgG
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Immunogen
A synthetic peptide corresponding to the carboxy terminus of the human histone H3 protein.
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Purification
Affinity Purified
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Conjugation
HRP
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Modification
Unmodified
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Form
Liquid
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Buffer System
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.